https://journals.eikipub.com/index.php/AIM-Medicine <p>The <strong>Annals of Innovation in Medicine (AIM)</strong> is a publication that provides a platform for researchers, physicians, and other medical professionals to share their findings, discoveries, and insights on various medical topics with a focus on innovation. It serves as a valuable resource for healthcare professionals who want to stay up-to-date with the latest developments and advancements in the field of medicine, particularly in areas related to new technologies, techniques, and processes.</p> <p><strong>ISSN <a href="https://portal.issn.org/resource/ISSN/2977-0335">2977-0335</a></strong></p> European Institute of knowledge and innovation (EIKI LTD) en-US Annals of Innovation in Medicine 2977-0335 https://journals.eikipub.com/index.php/AIM-Medicine/article/view/290 <p>Wunderlich syndrome is an uncommon pathology that is characterized by spontaneous hemorrhage in the subcapsular and perirenal spaces. We present the case of a 76-year-old woman who developed abdominal pain associated with hypotension after undergoing percutaneous transluminal angioplasty (PTA), with stenting in the right renal artery by means of puncture of the left brachial artery. An extensive retroperitoneal hematoma was identified on emission tomography in the topography of the right kidney, thus corroborating the diagnostic hypothesis of the aforementioned syndrome. As an outcome of the case, a surgical reapproach was required to drain a hematoma and hemostatic suture to resolve the condition.</p> Karen Kallás Pinto João Marco Braz Scarpa Mariano Pereira Otavio Cabral Coelho Rodrigo Duarte Berdun Silva Andrei Ricardo Rodrigues Guedes Ricardo Rodrigues Guedes Ana Clara Liz da Silva Cunha Alcedir Raiser Lima Raiser Lima Copyright (c) 2024 Annals of Innovation in Medicine https://creativecommons.org/licenses/by/4.0 2024-11-12 2024-11-12 2 4 10.59652/aim.v2i4.290 https://journals.eikipub.com/index.php/AIM-Medicine/article/view/320 <p>Datura is a well-known toxic plant, and several cases of death due to Datura intoxication have been reported. It has been documented as a plant with hallucinogenic properties. This study aimed to determine the biochemical and neurological effects of hydroethanolic seed extracts of Datura metel on the hippocampus and cerebellar cortex of adult rats. Twenty-five adult rats were assigned into five (5) groups (A, B, C, D, and E). Group A served as the negative control, and B served as the positive control, administered with lead acetate. While groups C, D and E were treated with 150mg/kg, 300mg/kg, and 600mg/kg body weight of the seed extracts. The animals were humanely sacrificed after 14 days of exposure. Haematoxylin, eosin stain, and immunohistochemical staining were carried out for neurofilament proteins (NFP) and neuro-specific enolase (NSE). Brain tissues for biochemical analysis were homogenized, and the level of superoxide dismutase (SOD), catalase, malondialdehyde, and glutathione S-Transferase were measured. Results showed a non-statistically significant increase in SOD, catalase, and GST. However, there was a statistically significant decrease in the level of MDA. Oral administration of hydroethanolic seed extracts of Datura metel in adult rats created changes in the histology of the hippocampus and cerebellar cortex of the rats, such as perineural vacuolation and apparent reduction in neuronal cells. The results of the immunohistochemical investigation point to a dose-dependent increase in NFP, while NSE was markedly expressed.</p> God'sman Eberechukwu Oboma Yibala Copyright (c) 2024 Annals of Innovation in Medicine https://creativecommons.org/licenses/by/4.0 2024-11-12 2024-11-12 2 4 10.59652/aim.v2i4.320