Evaluation of Side Effects of Anti-Seizure Drugs Among Sudanese Children with Epilepsy in Wad Medani Pediatric Teaching Hospital

Main Article Content

Salma Hassan Mohammed Eltahir
https://orcid.org/0009-0002-0738-154X
Salma Shani
https://orcid.org/0009-0002-0738-154X
Omda
Haydar
Ibrahim

Abstract

Abstract:


Background: Treatment of epilepsy with anti-seizure drugs (ASDs) for 2-5 years is important to control epileptic seizures.  Side effects of ASDs are well recognised and affect treatment outcomes if ASDs are severe.


Methods: A cross-sectional descriptive hospital-based study was conducted on 67 children with epilepsy on follow-up visits at a neurology referral clinic in Wad Medani Pediatric Teaching Hospital, Central Sudan, from February 2022 to July 2022.  Side effects of ASDs were measured using the Pediatric Epilepsy Side Effects Scale (PESQs).  Data were entered into the Statistical Package of Social Sciences (SPSS) version 20, and descriptive analysis was done to calculate frequencies and percentages and chi-square test for association.  The P-value of < 0.05 was considered statistically significant.


Results: Gender assessment showed that 36 (53.7%) of study patients were male.  43(64.2%) of participants had low severity of side effects, 14(20.9%) had low–moderate severity, and 8(11.9%) had no side effects. Significant associations were found between age and cognitive side effects (P-value .008); epilepsy type and cognitive side effects (P-value .026); seizure frequency and behavioural side effects (P-value .018); Type of ASD and behavioural side effects (P-value .000) and; type of ASD and neurological side effects (P-value .004).

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How to Cite
Eltahir, S. H. M., Shani, S. H. M. E., Taj El Deen, I. M. T. E. D., Babikir, H. E. H. B., & Omer, I. O. M. O. (2023). Evaluation of Side Effects of Anti-Seizure Drugs Among Sudanese Children with Epilepsy in Wad Medani Pediatric Teaching Hospital. Annals of Innovation in Medicine, 1(3). https://doi.org/10.59652/aim.v1i3.91
Section
Research Articles
Author Biographies

Salma Shani , Clinical pharmacy, wad Medani Pediatric Teaching Hospital, Ministry of Health

Clinical Pharmacist, Wad Medani Pediatric Teaching Hospital, Ministry of Health, Gezira State

Omda, Department of Pharmacology, Faculty of Pharmacy, University of Gezira

Department of Pharmacology, Faculty of Pharmacy, University of Gezira

Haydar, MD, CChN, FRCPCH. Consultant Paediatric Neurologist, Department of Paediatrics and Child Health, University of Gezira

MD, CChN, FRCPCH. Consultant Paediatric Neurologist, Department of Paediatrics and Child Health, University of Gezira

Ibrahim, Department of Clinical Pharmacy and Pharmacy Practice, Faculty of pharmacy, University of Gezira

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of pharmacy, University of Gezira

References

Albsoul-Younes, A., Gharaibeh, L., Murtaja, A. A., Masri, A., Alabbadi, I., & Al-Qudah, A. A. (2016). Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan. Neurosciences Journal, 21(3), 264-267.

Alsfouk, B. A. A., Brodie, M. J., Walters, M., Kwan, P., & Chen, Z. (2020). Tolerability of antiseizure medications in individuals with newly diagnosed epilepsy. JAMA neurology, 77(5), 574-581.

Berg, A. T., Berkovic, S. F., Brodie, M. J., Buchhalter, J., Cross, J. H., van Emde Boas, W., . . . Mathern, G. W. (2010). Revised terminology and concepts for organisation of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. In: Wiley Online Library.

Buraniqi, E., Dabaja, H., & Wirrell, E. C. (2022). Impact of antiseizure medications on appetite and weight in children. Pediatric Drugs, 24(4), 335-363.

Cavanna, A. E., Ali, F., Rickards, H. E., & McCorry, D. (2010). Behavioral and cognitive effects of antiepileptic drugs. Discovery medicine, 9(35), 138-144.

Dima, S. A., & Shibeshi, M. S. (2022). Antiepileptic drug adherence in children in southern Ethiopia: a cross sectional study. PLoS One, 17(2), e0263821.

Egunsola, O., Choonara, I., Sammons, H. M., & Whitehouse, W. P. (2018). Safety of antiepileptic drugs in children and young people: A prospective cohort study. Seizure, 56, 20-25.

Gerstner, T., Bell, N., & König, S. (2008). Oral valproic acid for epilepsy-long-term experience in therapy and side effects. Expert Opinion on Pharmacotherapy, 9(2), 285-292.

Helmstaedter, C., & Witt, J.-A. (2020). Anticonvulsant drugs and cognition. NeuroPsychopharmacotherapy, 1-12.

Ijff, D. M., & Aldenkamp, A. P. (2013). Cognitive side-effects of antiepileptic drugs in children. Handbook of clinical neurology, 111, 707-718.

Kaushik, S., Chopra, D., Sharma, S., & Aneja, S. (2019). Adverse drug reactions of antiepileptic drugs in children with epilepsy: a cross-sectional study. Current Drug Safety, 14(3), 217-224.

Kwong, K. L., Tsui, K. W., Wu, S. P., Yung, A., Yau, E., Eva, F., . . . Cheng, W. W. (2012). Utilisation of antiepileptic drugs in Hong Kong children. Pediatric neurology, 46(5), 281-286.

Larsson, K., & Eeg-Olofsson, O. (2006). A population based study of epilepsy in children from a Swedish county. European Journal of Paediatric Neurology, 10(3), 107-113.

Lee, Y. K., Ah, Y. M., Choi, Y. J., Cho, Y. S., Kim, K. J., & Lee, J. Y. (2016). Antiepileptic drug adherence and persistence in children with epilepsy attending a large tertiary care children’s hospital. Epileptic Disorders, 18(4), 408-417.

Loring, D. W., & Meador, K. J. (2004). Cognitive side effects of antiepileptic drugs in children. Neurology, 62(6), 872-877.

Mohammed, H., Lemnuro, K., Mekonnen, T., & Melaku, T. (2022). Adherence to anti-seizure medications and associated factors among children with epilepsy at tertiary Hospital in Southwest Ethiopia: a cross-sectional study. BMC neurology, 22(1), 310.

Ortinski, P., & Meador, K. J. (2004). Cognitive side effects of antiepileptic drugs. Epilepsy & Behavior, 5, 60-65.

Perucca, P., & Gilliam, F. G. (2012). Adverse effects of antiepileptic drugs. The lancet neurology, 11(9), 792-802.

Thigpen, J., Miller, S. E., & Pond, B. B. (2013). Behavioral side effects of antiepileptic drugs. US Pharm, 38(11), 15-20.